CD40LG and cold agglutinin disease: Individual patient case reports have also shown that bortezomib successfully cured patients with steroid/rituximab refractory IgM-mediated Cold agglutinin disease.[19] In our study, the efficacy and adverse reactions of the LowR-BD regimen in patients with rheumatism were also acceptable, which provides an alternative therapy for some refractory/recurrent rheumatic patients.