Levels of sFlt-1 rise roughly 5 weeks before manifestation of symptoms in women with preeclampsia, but PlGF levels fall before sFlt-1 levels rise.27 Hence, screening pregnant women during the first trimester to identify those at risk for preeclampsia could enable the use of low-dose aspirin to prevent maternal and neonatal complications.22 Here, PGF is linked to preeclampsia.