However, inhibition of type I IFN signaling at later time points using an anti-IFNAR neutralizing antibody led to dysfunctional CD8+ T cells in mice infected with West Nile virus (WNV), indicating that type I IFN may act as a redundant induction mechanism in the early phase of the CD8+ T cells response to arbovirus infection (75). The gene discussed is CD8A; the disease is arbovirus infection.