Point mutations in VCP induce multisystem proteinopathy type 1 (MSP1), which is known as inclusion body myopathy associated with Paget’s disease and frontotemporal dementia (IBMPFD)/amyotrophic lateral sclerosis (ALS) (27, 28, 64, 65). The gene discussed is ATAD1; the disease is amyotrophic lateral sclerosis.