Previous studies have suggested that cardiomyocyte‐derived exosomes can activate macrophages to get involved in the progression and resolution of post‐MI.22, 23 Moreover, a recent study by Chen et al. reported that TGF‐β has an indispensable role in repairing myocardial injury and promoting fibrosis by activating both Smad‐dependent and non‐Smad pathways.12 The gene discussed is TGFB1; the disease is myocardial infarction.