TP53 and neoplasm: We found that NEK2 overexpression and p53 knockdown separately could increase tumor growth, and this effect was significantly enhanced when the defects were combined in the H929‐TP53KO/NEK2 OE group; meanwhile, tumor growth was decreased in the H929‐TP53KO/shNEK2 group (Figure 4G,H, Figure S4D, Supporting Information).