H3K36 methylation, which is regulated by histone methylation modification‐related genes such as NSD3, PRMT1, SETD5, and SETD7, can promote gene transcriptional activation.[26] Our results showed that mRNA levels of these genes and H3K36me3 protein levels increase in TP53‐knockout MM cells (H929‐TP53KO). This evidence concerns the gene SETD5 and Miyoshi myopathy.