Genetic lesions (including translocation, amplification and mutations) and epigenetic changes (e.g., DNA methylation, microRNA regulation, and transcriptional regulation) cause aberrant gene expression.[17] To investigate the mechanisms underlying aberrant expression of NEK2 in MM, we first analyzed DNA copy number variations (CNVs) and expression of NEK2 by exome‐sequencing and RNA‐sequencing of 575 primary MM samples from the Multiple Myeloma Research Foundation (MMRF) CoMMpass database. The gene discussed is NEK2; the disease is plasma cell myeloma.