Treatment of SOX10 KD cells with DEPDC1B OE resulted in the partial rescue of melanoma cell proliferation (Figure 3e, Figure S3d, Supporting Information), colony formation (Figure 3f, Figure S3e, Supporting Information), invasion (Figure 3g, Figure S3f, Supporting Information), lung metastasis (Figure 3h, Figure S3g, Supporting Information), and CD31+ microvessel formation in lung nodules (Figure 3i) compared with SOX10 KD alone. The gene discussed is SOX10; the disease is melanoma.