Despite the detection of DEPDC1B expression in all stages of melanoma development, expression levels of SCUBE3 and CD31 were more pronounced and positively correlated in both primary (n = 62) and metastatic (n = 22) melanomas compared with very low or barely detectable expressions in nevi (n = 14) and normal skin tissues (n = 2) (Figure7a,b). The gene discussed is SCUBE3; the disease is melanoma.