In contrast to previous studies that found canonical WNT/β‐catenin signaling and RHO GTPase signaling function downstream of DEPDC1B to promote cancer cell migration and invasion,[10, 13, 15] we found that DEPDC1B KD and OE melanoma cells did not exhibit significantly altered signaling activities, ruling out their involvement in mediating the metastatic function of DEPDC1B. This evidence concerns the gene DEPDC1B and cancer.