We detected overlapping expressions of cytoplasmic DEPDC1B and SOX10 transcription factor in a large percentage of nevus, primary, and metastatic melanomas (86/98; 87.8%) compared with specimens expressing DEPDC1B alone (11/98; 11.2%) or expressing neither protein (1/98; 1%) (Figure 1e,f). Here, DEPDC1B is linked to nevus.