RHO and cancer: In contrast to previous studies that found canonical WNT/β‐catenin signaling and RHO GTPase signaling function downstream of DEPDC1B to promote cancer cell migration and invasion,[10, 13, 15] we found that DEPDC1B KD and OE melanoma cells did not exhibit significantly altered signaling activities, ruling out their involvement in mediating the metastatic function of DEPDC1B.