This differs from previous studies that showed DEPDC1B activated ERK activity through RAC1 to promote anchorage‐independent growth in oral cancer cells.[11] Altogether, our results showed that DEPDC1B promotes melanoma metastasis independent of canonical Wnt signaling and Rho GTPase signaling activities, which suggests other molecules are involved. This evidence concerns the gene RAC1 and lip and oral cavity carcinoma.