Hepatic insulin resistance is closely associated with increased sn‐1,2 diacylglycerol content, translocation of protein kinase C epsilon (PKCε) to the plasma membrane and subsequent inhibition of insulin receptor kinase activity (Lyu et al., 2020; Petersen et al., 2016; Samuel et al., 2007; Ter Horst et al., 2017). Here, PRKCE is linked to Insulin resistance.