INS and Insulin resistance: While the effects of exercise on insulin resistance during CC are unexamined, even a once-per-week (8 weeks), 30-min bout of eccentric RET (knee extensions) improved resting blood lipid profile (TG − 12.8%, TC − 8.8%, HDL-C 9.3%, LDL-C − 16.4%) and insulin sensitivity (resting glucose − 12%, insulin − 12%, homeostasis model assessment (HOMA) − 24%, HbA1C − 10.6%) in women, whereas equivalent concentric RET did not (Paschalis et al. 2011).