HLA-A and rheumatoid arthritis: Additional associations were also detected with HLA-B, HLA-DPB1, and HLA-A for ACPA-positive RA, with significantly lower effect size: 2.12 (95%CI 1.89–2.38) for aspartic acid (Asp) at position 9 of HLA-B; 1.40 (95%CI 1.31–1.50) for phenylalanine (Phe) at position 9 of HLA-DPB1; and 0.85 (95%CI 0.81–0.90) for asparagine (Asn) at position 77 of HLA-A.