In an analysis of a multiethnic Malaysian cohort, a strong risk of ACPA-positive RA was associated with Val at position 11 of HLA-DRB1; it was found that HLA-DQB1*03:02 allele was inversely related to the risk of developing ACPA-positive RA in the Malay population [39]. This evidence concerns the gene HLA-DQB1 and rheumatoid arthritis.