These include ABI3BP, coding for a constituent protein of the extracellular matrix (38), which undergoes extensive remodeling in osteoarthritis (60), AKT1S1, coding for a repressor of mTOR, which is a proposed drug target for osteoarthritis (52), and TPRM4 coding for a transient receptor ion channel activated by intracellular calcium levels (61), which are proposed to be altered in osteoarthritis chondrocytes as a response to mechanical stimuli (44). The gene discussed is ABI3BP; the disease is osteoarthritis.