P2RY12 and myocardial infarction: Aspirin and P2Y12 inhibitors have an antithrombotic effect through GPIIb/IIIa, which mainly contributes to platelet instability.27Although platelets are generally important for the arterial thrombus formation, thrombus formed at the culprit lesion of MI is mixed thrombus with high fibrin content,28, 29suggesting that coagulation system plays an important role in the formation of occlusive thrombus.