We further investigatedan association of SNPs in TLR4/AL160272.2 (rs1927914, rs7038716, rs7025144), SERPINA1 (rs1980616), ATXN2/BRAP(rs11065987), IL2RB (rs2284033), NT5C2 (rs11191582), CARD8 (rs11669386), ANG/RNASE4 (rs1010461), and ABTB2/САТ (rs2022318) genes with bronchial asthma (BA), arterial hypertension (AH) and their comorbidity. The gene discussed is RNASE4; the disease is breast angiosarcoma.