Considering a significantrole of genetic and environmental components in cognitive functioning, the present study aimed to estimatethe main effect of NGF (rs6330), NRXN1 (rs1045881, rs4971648), KIBRA (rs17070145), NRG1 (rs6994992), BDNF (rs6265),GRIN2B (rs3764030), APOE (rs7412, rs429358), and SNAP25 (rs363050) gene polymorphisms and to assess the effect ofgene-environment interactions on individual differences in spatial ability in individuals without cognitive decline aged18–25 years (N = 1011, 80 % women). Here, NRG1 is linked to Mental deterioration.