The content ofmiR-34c is also increased in the hippocampus in patientswith Alzheimer’s dementia and in hippocampal neurons inAPPPS1-21 transgenic mice exhibiting β-amyloid pathologyand cognitive deficits at an early age (Zovoilis et al., 2011).In turn, SIRT1 modulates synaptic plasticity and memoryformation through a miR-134-mediated mechanism (Gaoet al., 2010). Here, SIRT1 is linked to Cognitive impairment.