BMP2 and radiculopathy: However, in 2008, the FDA received 38 complaints of problems related to the use of BMP-2 in anterior cervical surgery that was performed “off-label.” A review by James et al. (2016) have listed all the clinical and preclinical side effects of BMP-2, including inflammatory complications, radiculopathy, ectopic bone, osteoclast activation and osteolysis, urogenital events, and wound complications [263].