ADIPOQ and Cognitive impairment: When participants were divided into three groups according to whether they had WMLs and cognitive impairment, group 1: the control group, group 2: patients with WMLs but without cognitive defects, and group 3: patients with both WMLs and cognitive defects, comparison of adiponectin level between 3 groups showed that adiponectin level was reduced significantly in group 3 compared with group 1 (p < 0.05) that adiponectin level was lower in patients with white matter lesions and cognitive impairment compared with the control group.