CCL5 and atherosclerosis: Similarly, it was reported that neutrophil-derived α-defensin can complex with CCL5 and be presented on EC, causing enhanced monocyte adhesion and vascular inflammation (254); while cathepsin G—also released from granules of neutrophils—is specifically deposited on the arterial endothelium of arteries but not on venule EC, promoting adhesion and extravasation of myeloid cells specifically in atherosclerosis-susceptible areas of vessels (255).