Experiments in mice could partly confirm the involvement of these adhesion molecules in atherosclerosis: Apoe−/−Icam1−/− mice displayed reduced atherosclerotic lesions (209) and similarly, fatty streak lesion area was smaller in mice deficient for either ICAM-1 or ß2-integrin (the common subunit of LFA-1 and Mac-1), but most distinctly for mice with a double knockout of both encoding genes (210). Here, ICAM1 is linked to atherosclerosis.