CXCL12 and coronary artery disorder: In line, Cxcl12 overexpression increased, while endothelial-cell specific Cxcl12 depletion reduced atherosclerotic lesion area in mice (366, 367) and platelet surface CXCL12 expression correlated with the risk of adverse cardiac events in symptomatic CAD patients undergoing percutaneous coronary intervention (PCI) (368).