Various key molecular mechanisms resulting in liver fibrosis have been revealed, such as chronic hepatocyte injury, endothelial barrier damage, inflammatory cytokines release, recruitment of bone marrow-derived cells (BMDCs), secretion of transforming growth factor-β (TGFβ) by macrophages, HSC activation, excessive accumulation of ECM, as well as the production of fibrous scars (Bataller and Brenner, 2005). This evidence concerns the gene TGFB1 and Hepatic fibrosis.