Depending on the LSEC response to liver injury, LSECs can promote liver regeneration by the CXCR7-ID1 pathway, or promote liver fibrosis via fibroblast growth factor receptor 1 (FGFR1)-CXCR4 pathway (Ding et al., 2014). This evidence concerns the gene FGFR1 and Hepatic fibrosis.