More importantly, regarding the Reactome terms, the outcome of GSEA indicated that in addition to the cell response to stress, different immunity-related pathways were associated with HSF2, including the adaptive immune response, TRIF (TICAM1)-mediated TLR4 signaling, MyD88-dependent TLR4 cascade, TLR3 cascade, TLR4 cascade, and various bacterial or viral infections. This evidence concerns the gene TLR3 and viral infectious disease.