Knockdown of FBP1 facilitates the HIF1 activation and upregulates the expression of glucose transporter 1 (GLUT1), lactate dehydrogenase A (LDHA), and hexokinase 2 (HK2) to increase aerobic glycolysis in HCC (Yang et al., 2019). Here, SLC2A1 is linked to hepatocellular carcinoma.