Moreover, we observed that DNA methylation was negatively correlated with HSF2 expression in many types of cancer, including ACC, BLCA, BRCA, CESC, CHOL, DLBC, ESCA, HNSC, KICH, KIRC, KIRP, LAML, LGG, LIHC, LUAD, LUSC, PAAD, PCPG, PRAD, SARC, SKCM, TGCT, THYM, UCEC, USC, and UVM (Supplementary Figure S6). This evidence concerns the gene HSF2 and cancer.