Another study showed that voluntary wheel running reduced tumor incidence and growth across 5 different tumor models, including subcutaneous injection of B16F10 murine melanoma cells, intravenous injection of B16F10 melanoma cells, diethylnitrosamine (DEN)—induced liver cancer, Lewis Lung carcinoma model, and Tg(Grm1)EPv transgenic male mice model. Here, GRM1 is linked to melanoma.