Based on our current data with COVID-19 (−) and COVID-19 (+) patients, there was a clear age-dependent effect (i.e., ≥65) on VFW:AG, VWF collagen binding activity, and the VWF:AG/ADAMTS13 activity ratio, suggesting an enhanced potential for endothelial coagulopathy. This evidence concerns the gene ADAMTS13 and COVID-19.