We will further report on the important role of hepatocyte growth factor (HGF)/c-mesenchymal-epithelial transition receptor (c-Met)-dependent signaling during NASH fibrogenesis, and describe a novel model of iron overload-associated liver fibrosis uncovering lysosomal iron overload as a novel pro-fibrotic mechanism. This evidence concerns the gene MET and metabolic dysfunction-associated steatohepatitis.