TNF and liver disorder: Administration of mNOX-E36 during the regression phase of these murine models of liver disease, however, significantly accelerated fibrosis resolution, by causing a shift in hepatic dominance from the pro-inflammatory, tumor necrosis factor (TNF)-secreting, Ly6Chigh MoMΦs toward “restorative” Ly6Clow MoMΦs (105).