Noteworthy, the mineralocorticoid receptor (MR), which has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, on myeloid cells (i.e., macrophages), might contain protective HGF/c-Met signaling in hepatocytes whereby these two cells could be functionally linked in the formation of steatohepatitis and related fibrosis (44). This evidence concerns the gene HGF and Insulin resistance.