Methionine- and choline-deficient diet (MCDD) or prolonged high fat diet (HFD) induced murine NASH characterized by steatosis and immune cell infiltrates, display increased hepatic mRNA expression of IL-1β, NLRP3, caspase 1, and ASC alongside elevated caspase-1 activity (137, 138). The gene discussed is CASP1; the disease is metabolic dysfunction-associated steatohepatitis.