A previous study has demonstrated that PPARG promoter hypermethylation correlated with severe fibrosis in liver biopsies (37), and more recently Hardy et al. found a similar degree of hypermethylation in the PPARG promoter in plasma ccf-DNA and hepatocyte-rich tissue captured by laser capture microdissection, suggesting that plasma DNA methylation of PPARG could potentially be used as a noninvasive method to determinate liver fibrosis severity in patients with MAFLD (38). The gene discussed is PPARG; the disease is Hepatic fibrosis.