Surprisingly, Epi_HSPA1A, Epi_GSTA1, Epi_SPP1 showed two distinctive CNV states between normal and tumor tissue (Figure 2C, Supplementary Figure S2C), according to which we divided these cells into two clusters, ductal-normal cells from normal tissues and ductal-tumor cells from tumor tissues. The gene discussed is SPP1; the disease is neoplasm.