We found that LGALS9_CD44, MIF_TNFRSF14, CD47_SIRPG, MDK_LRP1 and LGALS9_HAVCR2, CD74_COPA, C3_C3AR1, ANXA1_FPR3 interactions were upregulated in both ductal-tumor and malignant cells versus ductal-normal. This evidence concerns the gene COPA and neoplasm.