ISG15 and neoplasm: To find new potential checkpoints, we investigated the cell-cell communications between tumor-promoting immune cells (CD4_CXCL13, CD4_FOXP3, CD8_CXCL13, CD8_ISG15, Mac_C1QA, Mac_ISG15, Mac_SPP1 and cDC3_LAMP3) and the ductal epithelial cells (Figure 2J).