Juan Lin et al. also found that in Ldlr−/− mice, the area of advanced atherosclerotic plaques in RIPK3 knockout mice was significantly reduced, and the number of programmed necrotic macrophages in the lesion was less than that in wild mice, but there was no significant difference in the number of apoptotic cells, suggesting that RIPK3-dependent necroptosis was closely related to the development of advanced atherosclerosis (Lin et al., 2013). The gene discussed is RIPK3; the disease is atherosclerosis.