NPY5R and metastatic malignant neoplasm in the lymph nodes: Furthermore, we analyzed the correlations of NPY5R expression and methylation with clinicopathological features (Supplementary Figures S2A–L), and found that decreased NPY5R expression was correlated with lymph node metastasis (N1 vs. N0, p = 0.04) and depth of invasion (T4/T2 vs. T1, p < 0.05) (Supplementary Figures S2D,F).