VEGFA and diabetic foot: For instance, inhibiting miR-217 can upregulate hypoxia-inducible factor-1 (HIF-1α)/vascular endothelial growth factor (VEGF) pathway to promote angiogenesis in diabetic foot ulcer rats and effectively improve inflammatory response by decreasing inflammatory factors (IL-1β, TNF-α, and IL-6) (Lin et al., 2019).