This pattern could be highly relevant for treating high-frequency hearing disorders involving dysfunction of basal hair cells, such as DFNA2 (Kharkovets et al., 2006; Carignano et al., 2019), DFNA3 (Smith and Ranum, 1993), DFNA5 (Laer et al., 1998), DFNA9 (Robertson et al., 1998), and DFNA17 (Lalwani et al., 2000). This evidence concerns the gene GSDME and hearing disorder.