Although the study did not define whether this pathway was frequently invoked upon DNA damage in cancer cells (beyond the case of PMA-differentiated THP-1 cells), it is noteworthy that this alternative STING pathway favored the activation of NF-κB driven pro-inflammatory factors such IL-6, with limited IRF3 signaling (Dunphy et al., 2018). This evidence concerns the gene IRF3 and cancer.