IFNB1 and cancer: While it is clear that STING activation of the immune-cell compartment of the tumor microenvironment can have strong anti-tumoral activities, owing to production of anti-proliferative IFN-β (Parker et al., 2016) and the ensuing recruitment of CD8+T cells (Diamond et al., 2011), the cell-intrinsic role of STING signaling on the growth of cancer cells remains poorly defined.