In Chen’s study of esophageal squamous cell carcinoma, up-regulated LINC-POU3F3 promoted the upregulation of tumor cell stem cell markers (CD133, CD44 and CD90), thereby enhancing the radiotherapy resistance of tumor cells and increasing the degree of malignancies of esophageal cancer (Chen et al., 2021b). This evidence concerns the gene POU3F3 and neoplasm.