MUC16 and squamous cell carcinoma: Moreover, FAT1 mutation information has been repeatedly detected in human cancers, especially in squamous cell carcinoma (Mountzios et al., 2014); MUC16 was recognized as the third most common mutant oncogene (Bafna et al., 2010); HRAS was a member of the RAS family of oncogenes, and its mutation has been confirmed to be closely related to the initiation of OSCC (Chai et al., 2020).