Moreover, FAT1 mutation information has been repeatedly detected in human cancers, especially in squamous cell carcinoma (Mountzios et al., 2014); MUC16 was recognized as the third most common mutant oncogene (Bafna et al., 2010); HRAS was a member of the RAS family of oncogenes, and its mutation has been confirmed to be closely related to the initiation of OSCC (Chai et al., 2020). This evidence concerns the gene FAT1 and squamous cell carcinoma.