GATA2 and acute lymphoblastic leukemia: Furthermore, in-situ high-through chromosome conformation capture (Hi-C) data for both the B-ALL cell line Nalm6 and neuroblastoma cell line Kelly (Figure 5C) from GenomePaint (30) showed that the deletion overlapped with the boundary of topologically associating domain (TAD) harboring GATA2. Disruption of the TAD structure by the deletion might aberrantly connect the GATA2 promoter to the active regulatory DNA elements in the adjacent TAD, thus contributing to GATA2 dysregulation in cis.