DUX4 and acute lymphoblastic leukemia: These 13 B-ALL cases included five with high hyperdiploid (HYPER), two with KMT2A rearrangements (MLL), two with ETV, and one each with DUX4 rearrangement (DUX4), low hypodiploid (HYPO), BCR-ABL1 (PH), and BCR-ABL1-like (PHL) (Figure 1C).