KLF1 and acute lymphoblastic leukemia: Notably, there were several known tumor-associated genes (highlighted in Figure 2A) among these 33 target genes, including BAG3, EPOR, and KLF1. BAG3, which was reported to be an anti-apoptotic gene involved in leukemic cell survival and response to therapy (36), was among the most significant DEGs between GATA2-outlier and GATA2-normal B-ALL patients (p-value = 7.9 × 10−14; log2FC = 3.4, Figure 3B).