To better understand the role of Cdc4 during the infection progression, we examined the fungal burdens in lungs infected by wild-type H99 and cdc4Δ mutant at 1, 3, 5, 7, 9, 11, 13, and 15 dpi and visualized the development of fungal lesions in Methenamine silver-stained slides. The gene discussed is FBXW7; the disease is infection.