ATRX and cancer: In recent years, with whole-genome sequencings in cancer, ATRX mutations/losses have been detected in a variety of cancers, such as PanNETs (104–106), Glioblastoma multiforme (GBM) (101), neuroblastoma (107), adrenocortical tumor (96, 97), pediatric osteosarcoma (108), angiosarcomas (109), and Gliomas (99).