Of the three genes, CXCR3 had significant associations with OS of patients with HNSCC (HR, 0.64; 95% CI, 0.49–0.84; log-rank p = 0.001), so did CCR5 (HR, 0.76; 95% CI, 0.58–1; log-rank p = 0.048). Here, CXCR3 is linked to head and neck squamous cell carcinoma.