Other studies have shown that allele A of SR-B1 exon 1 in male patients with CAD can lead to the increase of serum HDL-C and apoA1 levels; thus, the SR-B1 exon 1 polymorphism may be related to the susceptibility to CAD and the severity of coronary heart disease in the Tianjin Han population [94]. The gene discussed is SCARB1; the disease is coronary artery disorder.