Farnesoid X receptor (FXR) activated by obeticholic acid (OCA) increases the expression of SR-B1 in the liver, and recent studies have shown that the combination of OCA and the LXR agonist, GW3965, can significantly increase the levels of mRNA and SR-B1 in the liver of hamsters with hypercholesterolemia, providing direct evidence that the synergistic activation of SR-B1 gene transcription by FXR and LXR plays a role in hepatic lipid metabolism [98]. The gene discussed is NR1H4; the disease is familial hypercholesterolemia.