TNF and breast cancer: Through similar screening criteria, the median values of BC, CC, DC, EC, IC, and LAC were calculated, 9 refined key targets (estrogen receptor- (ESR-) 1, protooncogene c-Fos (FOS), mitogen-activated protein kinase- (MAPK-) 1, MAPK14, Rela (p65 NF-κB), TP53, TNF, transcription factor activator protein-1 (Jun), and Myc proto-oncogene protein (Myc)) were found because their median values of BC, CC, DC, EC, IC, and LAC were greater than 6.510, 0.591, 8.000, 0.156, 4.935, and 5.500, respectively (Figure 2).