Besides these HF related biomarker proteins, several disease related proteins also showed a different level of upregulation between Yang deficiency and Qi-yin deficiency patients, such as serum amyloid A-2 (SAA2, upregulated 41-fold and 17-fold, respectively) and Myosin-15 (MYH15, upregulated 9-fold and 5-fold, respectively). The gene discussed is MYH15; the disease is yang deficiency.