A study by Koumangoye et al. implicated EZH2 and HDAC3 as indirect targets of miR-31 in esophageal cancer cells as their upregulation was associated with raised levels of miR-31 by directly regulating SOX4, which then acts on EZH2 and HDAC3 [125]. This evidence concerns the gene EZH2 and esophageal cancer.