TP53 and neoplasm: Of the non-DE genes, Zmiz1 is a prognostic marker of multiple cancer types (Mathios et al., 2019), Rpl37a is a biomarker for response to neoadjuvant chemotherapy in non-metastatic locally advanced breast cancer (Carrara et al., 2021), and Hipk1 has been shown to act as a tumor suppressor by activating p53 (Rey et al., 2013).