CHD8 and cancer: Finally, blocks 143 (160 kb, Figure 4E) and 162 (80 kb, Figure 4F) had several genes that either encoded chromatin remodeling factors (Supt16h and Chd8), genes representing families often mutated in cancers (Tox4, Yu and Li, 2015), genes that have been implicated as oncogenes as well as tumor suppressors (Sall2, Hermosilla et al., 2017; Mettl3, Zeng et al., 2020) and involved in glycosylation (Large1, block162) which is used as a marker and offers novel therapeutic targets (Costa et al., 2020).