Meanwhile, serine protease inhibitors are inhibitors of blood coagulation factors (Seixas et al., 2007), and we have found the expression level of SERPINA5, SERPINF2 and SERPING1 were uniquely increased in the lung of gayal, and the corresponding log2 fold changes of 1.80, 3.06, and 1.48, which may play an important role in the mechanism of pulmonary edema resistance, thus reducing the risk of pulmonary edema. The gene discussed is SERPINA5; the disease is pulmonary edema.