EDNRA encodes the endothelin 1 (EDN1) receptor, a gene involved in the vasoconstriction mechanism (Sharma et al., 2014), as well as closely related to pulmonary hypertension and HIF activity, which is positively selected in Tibetan (Simonson et al., 2010). The gene discussed is EDN1; the disease is pulmonary arterial hypertension.