The SNP rs4789936 on TIMP-2 was observed to decrease the risk of alcohol-induced osteonecrosis of the femoral head (ONFH) in the Chinese Han population under allele, dominant, overdominant, and log-additive models after adjusting for age and sex (Chen et al., 2016). The gene discussed is TIMP2; the disease is familial avascular necrosis of femoral head.