Thus, increased PMN responses, reflected by increased PMN numbers or, more specifically, a high neutrophil-to-lymphocyte ratio (NLR) in peripheral blood, are associated with an increased likelihood of intracerebral hemorrhage, death and poor neurological outcome at 3 months post-stroke, as assessed by the modified Rankin Scale (mRS) score in patients receiving tissue plasminogen activator (tPA)-induced thrombolysis (12). The gene discussed is PLAT; the disease is stroke disorder.