CD226 and Miyoshi myopathy: As already mentioned, other activating receptors were proved to be downregulated in MM, including DNAM-1, 2B4 (CD244), and CD16 (165, 261). TGF-β was confirmed as one of the factors causing the downregulation of 2B4 and 2B4 adaptor proteins (DAP10 and SAP) (278, 279).