However, ZNFX1 appears as an early sensor of dsRNA: as opposed to RIG-I and MDA5 whose expression and mitochondrial translocation is induced only following viral infection, ZNFX1 is constitutively localized within mitochondria and its expression, further increased by viral infection, reaches a peak much earlier than RIG-I and MDA5. The gene discussed is IFIH1; the disease is viral infectious disease.