Indeed, by performing iCLIP against OAS1, infection by SARS-CoV-2 was shown to enhance the RNA-binding activity of OAS1, which interacts primarily with highly structured host RNAs (e.g. snoRNAs, lncRNAs, intronic regions of mRNAs) as well as with specific stem loops (SL1 and SL2) located withing the first 54 nucleotides of the 5’UTR of all positive-sense SARS-CoV-2 RNAs (80, 106). Here, OAS1 is linked to infection.