IFIT1 and viral infectious disease: For example, IFIT1 (interferon-induced protein with tetratricopeptide repeats 1), induced by IFN-α/β upon viral infection, binds a triphosphate group on the 5’ terminal of viral RNAs (PPP-RNA) (244) in a sequence-independent manner and form a complex with IFIT2 and IFIT3 (and other proteins from IFIT family) to physically sequester the viral RNA and limit the assembly of viral particles (see Figure 5A) (245, 246).