Alternatively, the number of remission of AD per 1 person-year, which is the sum of the patient AD duration, was highest in IKAROS deficiency before the onset of hypogammaglobulinemia, whereas remission was achieved in a few patients with CTLA4 deficiency (Figure 4F). This evidence concerns the gene CTLA4 and hyperinsulinemic hypoglycemia, familial, 4.