Tfh are a subset of CD4+ T cells in the germinal center that express CXCR5 and provide help to B cells for antibody production; circulating Tfh (cTfh) are considered a counterpart of Tfh, and alterations in the frequency of cTfh have been described in several autoimmune conditions (49). This evidence concerns the gene CXCR5 and Autoimmunity.