Although FKBP4 has been demonstrated to connect mammalian target of naringenin complex 2 (mTORC2) and phosphoinositide-3-kinase (PI3K) to enhance cell proliferation of BC, for the first time, we found that FKBP4 played a carcinogenic role by downregulating NRF2 in BC cells and co-cultured DCs. The gene discussed is NFE2L2; the disease is breast cancer.