In this study, we showed that naringenin, a flavonoid shown to have anti-tumor effects in various carcinomas in other studies (25), suppressed both autophagy and proliferation via new-found FKBP4/NR3C1/NRF2 signaling pathway in luminal A and basal-like subtype of BC cells. Here, FKBP4 is linked to neoplasm.