NR3C1 and neoplasm: The NR3C1 (nuclear receptor subfamily 3, group C, member 1/glucocorticoid receptor) normally resides in the cell cytoplasm, where the NR3C1 protein translocates to the nucleus when bound to glucocorticoids, and thus is involved in growth, reproduction, metabolism, immune and inflammatory reactions, and cardiovascular functions and tumor cellular proliferation and differentiation (22).