The authors found six ERα mutations (E380Q, L536Q, Y537C, Y537S, Y537N, and D538G) in plasma from patients with advanced PCa, and six ERα and ERβ isoforms (ERα-66, ERα-36, ERβ1, ERβ2, ERβ4, and ERβ5) (19). Here, ESR2 is linked to posterior cortical atrophy.