Conversely, the activation of ERβ induces anti-tumoral activity in PCa cells by repressing key oncogenes (PI3K, p45Skp2, c-Myc, and cyclin E, and the oncogenic TMPRSS2-ERG fusion), by increasing the expression of antiproliferative genes (PTEN, FOXO3, KLF5, p21WAF1, CDKN1A, and p27Kip1) as well as E-cadherin (37). Here, ESR2 is linked to posterior cortical atrophy.