Our data showed that the average of serum concentration of IL-2 (2.24 ± 1.18 vs. 3.10 ± 0.92, p = 0.00, Figure 1A), IL-4 (2.12 ± 0.99 vs. 3.22 ± 0.86, p = 0.00, Figure 1B), IL-10 (3.56 ± 4.19 vs. 7.40 ± 3.09, p = 0.00, Figure 1D), TNF-α (2.04 ± 1.74 vs. 4.29 ± 1.21, p = 0.00, Figure 1E) and IFN-γ (3.46 ± 10.07 vs. 6.01 ± 2.23, p = 0.00, Figure 1F) in the children with TD were significantly lower than those in the control group, while IL-6 (12.31 ± 28.53 vs. 7.34 ± 4.73, p = 0.00, Figure 1C) was significantly higher than that in the control group. Here, IL4 is linked to thanatophoric dysplasia.